Seattle Seahawks at San Francisco 49ers — 8:20 P.M.
Candlestick Park, San Francisco
Despite having the NFC's second-worst offense, Seattle (4-2) has found a way to win close games behind rookie quarterback Russell Wilson. Seahawks' running back Marshawn Lynch, the NFC's top rusher, will need to gain ground against a 49ers' defense that allows 275.8 yards per game, the fewest in the league. Quarterback Alex Smith had a dreadful game for San Francisco (4-2) in last week's loss to the Giants. The Seahawks, who have the league's fourth-ranked defense, will look to cause more trouble for Smith via the pass rush, especially with left tackle Joe Staley likely out with a concussion.